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  4. Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF): Its benefits and how it will make a difference

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Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF): Its benefits and how it will make a difference

31 May 2025

Episode: May 2025

Presenters: Chris Nellessen, Principal Mass Spectrometrist, Department of Agriculture, Fisheries and Forestry. Dr Dominie Wright, Principal Laboratory Scientist, Diagnostics and Laboratory Services, Department of Primary Industries and Regional Development, WA.

Summary: Chris discussed what MALDI-ToF is, the benefits it has brought to the department, and how the technology works. He also described what kind of samples can be analysed with the technology, and how the team have improved upon the standard approach of using it to make the technology a more effective and easily used diagnostic tool for plant pests. He also discussed some of the different challenges that remain and provided an overview of what is being done to expand the scope of this technology’s diagnostic capability in the plant pest diagnostic space. Dominie discussed her experiences using MALDI-ToF mass spectrometry and the highs and lows associated with using the technology in identifying bacteria.

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Page last updated: 17 July 2025

We acknowledge the continuous connection of First Nations Traditional Owners and Custodians to the lands, seas and waters of Australia. We recognise their care for and cultivation of Country. We pay respect to Elders past and present, and recognise their knowledge and contribution to the productivity, innovation and sustainability of Australia’s agriculture, fisheries and forestry industries.

Artwork: Protecting our Country, Growing our Future
© Amy Allerton, contemporary Aboriginal Artist of the Gumbaynggirr, Bundjalung and Gamilaroi nations.

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